Member, La Jolla Institute for Allergy and
Dr. Hogan’s research centers on cellular signaling pathways. Dr. Hogan has collaborated extensively with Dr. Anjana Rao on projects including the identification of the calcium/calcineurin-regulated transcription factor NFAT, detailed studies of calcineurin-NFAT transcriptional signaling, and most recently the identification of the CRAC channel component Orai1. As Senior Director, Inflammation Research, at The CBR Institute for Biomedical Research Laboratories from 1998 to 2000, he developed novel peptide and nonpeptide inhibitors of calcineurin-NFAT signaling, an early example of blocking signaling in immune cells by targeting a protein-protein interaction. He maintains an active interest in further applications of this approach. From 1986 to 1996 Dr. Hogan headed a group in the Department of Neurobiology at Harvard Medical School, studying the molecular basis of inflammatory pain. His laboratory pioneered the use of sensory neurons in culture for biochemical and electrophysiological investigations of pain mechanisms, and collaborated in developing the ND7 sensory neuron cell line that has found wide use in studies related to pain, local anesthetics, and herpesvirus latency. In addition to his research, Dr. Hogan has taught biochemistry and neuroscience at Harvard for more than twenty years. Dr. Hogan received an AB in Mathematics from Harvard College, and completed his PhD and postdoctoral training in Neurobiology at Harvard Medical School. Dr. Hogan has been an Investigator at The CBR Institute for Biomedical Research, Inc. since 1996.