PRESS RELEASES

NOVEMBER 7, 2019

CalciMedica to Present Results of PD/PK Study in Acute Pancreatitis Patients for its CRAC Channel Inhibitor CM4620 at APA Annual Meeting

OCTOBER 30, 2019

Henry Ford Hospital Physician Presents Results from the Initial Patient Study of CalciMedica’s CRAC Channel Inhibitor CM4620 in Acute Pancreatitis at ACEP Meeting

MARCH 26, 2019

CalciMedica Names Life Science Veteran to its Board of Directors

MARCH 19, 2019

CalciMedica, Inc. to Present Study Population Profile from its Initial Patient Study of its CRAC Channel Inhibitor CM4620 in Acute Pancreatitis at International Conference

MAY 1, 2018

CalciMedica Names Two Senior Executives to its Board of Directors

JANUARY 24, 2018

Research Collaboration between the San Francisco VA, UCSF and CalciMedica, Inc. to Present Results on CRAC Channel Inhibitors in a Stroke Model at International Conference

MAY 24, 2017

CalciMedica Receives Fast-Track Designation for CM4620, a Novel CRAC Channel Inhibitor to Treat Acute Pancreatitis

JANUARY 6, 2017

CalciMedica Initiates Phase 1 Clinical Studies for CRAC Channel Inhibitor

NOVEMBER 15, 2016

San Francisco VA, UCSF and CalciMedica, Inc. Present Results on CRAC Channel Inhibitors in Traumatic Brain Injury Model at Neuroscience Meeting

NOVEMBER 14, 2016

CalciMedica Announces Senior Clinical Development Hire

FEBRUARY 16, 2010

CalciMedica Announces Issuance of US Patent No. 7,645,588, a Composition Patent Involving STIM1, a Key Component of the CRAC Channel

DECEMBER 15, 2009

CalciMedica Achieves Milestone and Draws Down Second Tranche of $12 Million Series C Financing

OCTOBER 13, 2009

CalciMedica Appoints Evelyn Graham to its Board of Directors

OCTOBER 13, 2008

CalciMedica Exercises Option to Acquire Additional Intellectual Property from TorreyPines Therapeutics

May 7, 2007

CalciMedica Acquires Exclusive Rights to Novel Immune Signaling Targets for Treating Autoimmune Diseases from the CBR Institute

MAY 7, 2007

TorreyPines Therapeutics Transfers Intellectual Property and Compounds for Treating Autoimmune Diseases to CalciMedica

PUBLICATIONS AND PRESENTATIONS

CELL CALCIUM 74: 147-159, 2018

Kenneth A. Stauderman. CRAC channels as targets for drug discovery and development. Cell Calcium 74: 147-159, 2018.

THE JOURNAL OF PHYSIOLOGY 597.12: 3085–3105, 2019

Richard T. Waldron, Yafeng Chen, Hung Pham, Ariel Go, Hsin-Yuan Su, Cheng Hu, Li Wen, Sohail Z. Husain, Catherine A. Sugar, Jack Roos, Stephanie Ramos, Aurelia Lugea, Michael Dunn, Kenneth Stauderman, and Stephen J. Pandol. The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis. The Journal of Physiology 597.12: 3085–3105, 2019.

GASTROENTEROLOGY 149: 481-492, 2015

Wen, L., Voronina, S., Javed, M.A., Awais, M., Szatmary, P., Latawiec, D., Chvanov, M., Collier, D., Huang, W., Barrett, J., Begg, M., Stauderman, K., Roos, J., Grigoryev, S., Ramos, S., Rogers, E., Whitten, J., Velicelebi, G., Dunn, M., Tepikin, A.V., Criddle, D.N., Sutton, R. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology 149: 481-492, 2015.

CELL CALCIUM 42: 133-144, 2007

Michael D. Cahalan, Shenyuan Zhang, Andy Yeromin, Kari Ohlsen, Jack Roos, and Kenneth A. Stauderman. Molecular basis of the CRAC channel. Cell Calcium 42: 133-144, 2007.

PNAS 103: 9357-9362, 2006

Zhang, S.L., Yeromin, A.V., Zhang, X.H.-F., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman, K.A., and Cahalan, M.D. Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity. PNAS 103: 9357-9362, 2006.

NATURE 437: 902-905, 2005

Zhang, S.L., Yu, Y., Roos, J., Kozak, J.A., Deerinck, T.J., Ellisman, M.H., Stauderman, K.A., and Cahalan, M.D. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 437: 902-905, 2005.

J. CELL BIOLOGY 169: 435-445, 2005

Roos, J., DiGregorio, P.J., Yeromin, A.V., Ohlsen, K., Lioudyno, M., Zhang, S., Safrina, O., Wagner S., Cahalan, M.D., Velicelebi, G., and Stauderman, K.A. STIM1, an essential and conserved component of store-operated calcium channel function. J. Cell Biology 169: 435-445, 2005.

J. GEN. PHYSIOL. 123: 167-182, 2004

Yeromin, A.V., Roos, J., Stauderman, K.A., and Cahalan, M.D. A store-operated calcium channel in Drosophila S2 cells. J. Gen. Physiol. 123: 167-82, 2004.