Technology Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity PNAS June 13, 2006 A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Nature April 2, 2006 STIM1, an essential and conserved component of store-operated Ca2+ channel function Journal of Cell Biology May 2, 2005