CalciMedica is headquartered in San Diego, CA.
CRAC Channel Biology
CalciMedica’s lead clinical compound, AuxoraTM, is a potent and selective small molecule inhibitor of Orai1-containing CRAC channels that is being developed for use in patients with diseases that have respiratory dysfunction, including ARDS as a major component. Such diseases include severe COVID-19 pneumonia, acute flu pneumonia with respiratory failure/ARDS, and acute pancreatitis with accompanying systemic inflammatory response syndrome (SIRS). Evidence suggests that CRAC channels play a role in inflammation-induced injury of pulmonary endothelial cells, resulting in loss of alveolar-capillary barrier function and accumulation of fluid in the alveoli. Similarly, hyperactivation of CRAC channels results in excessive calcium influx into pancreatic acinar cells and plays a pivotal role in cellular injury and the progression of acute pancreatitis. In each of these settings, local and systemic inflammation can lead to organ failure and death. Auxora has demonstrated reduced ventilator use and mortality as well as improved time to recovery in patients with severe COVID-19 pneumonia on low-flow supplemental oxygen therapy. In patients with hypoxemia secondary to SIRS from acute pancreatitis, Auxora has been found to accelerate patient recovery, decrease hospital stay and potentially protect lung and kidney function.
CalciMedica is also exploring other acute indications for Auxora such as viral pneumonia, acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI).