About Us

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Pre-2007

Dr. Ken Stauderman and collaborators discovered the role of STIM1, in conjunction with Orai1, in forming CRAC channels targeted by CalciMedica’s drug compounds.

Pre-2007

2007

CalciMedica was founded by scientists from TorreyPines Therapeutics, including Dr. Stauderman, CalciMedica’s Co-founder and Chief Scientific Officer, and a team from Harvard’s CBR Institute for Biomedical Research comprised of Drs. Anjana Rao, Patrick Hogan (both currently at the La Jolla Institute for Immunology) and Stefan Feske (currently at NYU School of Medicine).

2007

2007-Present

At CalciMedica, Dr. Stauderman and a team of skilled scientists developed a series of proprietary assays that led to the identification and optimization of a portfolio of potent and highly selective CRAC channel inhibitors.

2007-Present

2011-2012

CalciMedica advanced the first CRAC channel inhibitor into human clinical studies.  This compound demonstrated safety and trends towards efficacy as an orally administered agent in patients with moderate to severe plaque psoriasis.

2011-2012

2012-2016

Different CalciMedica CRAC channel compounds were developed with improved potency and selectivity; CM4620 (the intravenous (IV) formulation of which was named AuxoraTM) was selected for development.

2012-2016

2017-Present

AuxoraTM entered into clinical development, proceeding through Phase 1 studies in healthy volunteers and several Phase 2 studies in patients with acute pancreatitis and accompanying systemic inflammatory response syndrome (SIRS) as well as severe and critical COVID-19 pneumonia, again demonstrating safety and efficacy.

2017-Present

2020-Present

In conjunction with St Jude Children’s Research Hospital, an Investigator-Initiated Clinical Trial was launched in pediatric cancer patients with acute lymphocytic leukemia (ALL) that develop acute pancreatitis in response to a specific chemotherapeutic agent used to treat ALL.

2020-Present

2020-Present

Several promising oral CRAC channel inhibitor drug candidates are in preclinical development to address chronic inflammatory conditions.  We expect to enter clinical development with one of these compounds in the setting of chronic pancreatitis in H1 2022.

2020-Present

2020-Present

The clinical profile for AuxoraTM suggests broad application in different acute inflammatory diseases in critically ill patients, potentially including acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI).

2020-Present
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